Apoquel? can be given with or without food. For some dogs, we prescribe it twice daily (morning and night) for a short period of time, then reduce to once per day. For others, we start at once per day. If given once daily, it can be given either morning OR night, depending on when your dog seems most itchy. Ideally, Apoquel? should not be used twice daily over a long period of time, as this may increase the chances for side effects.