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An un-neutered female dog will usually come into her first season at around 6 months old, although smaller breeds can come into season earlier and larger breeds a while later (sometimes not until they're 12 months old). From then on, she'll have a season roughly every 6 months.
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On average, puberty (or sexual maturity) is reached at about six months of age, but this can vary by breed. Smaller breeds tend to have their first estrous cycle at an earlier age, while large and giant breeds may not come into heat for the first time until they reach eighteen months to two years of age.

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