To treat a ganglion cyst, start by evaluating how serious your cyst is. If the cyst is pressing on a nerve painfully, or if it's so large that you can't move the joint properly, see your doctor for treatment. Otherwise, manage the cyst at home by taking an over-the-counter pain medication and avoid pressing, thumping, or puncturing the cyst. Most cysts will naturally go away by themselves, so the hardest part is just waiting for that to happen! If your cyst is getting worse or swells to a ...