Let it soak into the skin and for the medication activate. Drink a beer, have a smoke, go yell at your neighbors kids.. do whatever you want, but let it sit and soak in for at least 10 minutes. AFTER 10 MINUTES, RINSE OFF MEDICATED SHAMPOO Rinse medication off of your American Bully, Pit Bull, Bulldog or related breed dog/puppy with water.