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Trazodone is commonly prescribed as a sleep aid for patients prescribed antidepressants in the selective serotonin reuptake inhibitor class.

A recent single dose pharmacokinetic study of Trazodone in six dogs, found that when given orally, Trazodone produced mild sedation with no observable side effects.

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A recent single dose pharmacokinetic study of trazodone in six dogs, found that when given orally, trazodone produced mild sedation with no observable side effects. In anesthetized dogs, trazodone has been shown to have very little effect on cardiac function, compared with equally effective dosages of imipramine.
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Trazodone provides mild sedation and decreases anxiety in dogs. This medication normalizes levels of serotonin within the brain.
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Trazodone for sedation in dogs

  • Pre-Hospital Sedation Options for Aggressive and Anxious Dogs. Trazodone is classified as a serotonin receptor antagonist and reuptake inhibitor (SARI), 2,6,7 used primarily in the acute hospital setting to manage anxious patients 6 as well as long term as a single or adjunctive agent in dogs with anxiety disorders.

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