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Lifecycle of canine parvovirus?
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asked
Mar 5, 2022
by
TerryMulvihill
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1
Answer
–1
vote
answered
Aug 30, 2022
by
PeterTaylor
Briefly:
Cells are exposed to parvovirus and take it up.
Some trigger causes parvovirus to release its genetic
material.
Host cells begin to replicate the parvovirus; parvovirus is
100% dependent on its host for replication machinery.
Viral particles are released.
Specifically:
Canine parvovirus is a small non-encapsulated single-stranded
DNA virus related to feline panleukopenia virus. It binds to the
canine (and in some cases feline) transferrin receptor. It is
probably taken up through clathrin-mediated endocytosis according
to Parrish et al in J Virol 2004 Jul;78(13):6709-14. An as-yet
unknown trigger causes the release of its ssDNA. The DNA then uses
host ribosomes to synthesize its VP1 and VP2 (capsid) proteins as
well as its NS1 and NS
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