How long does it take prostate cancer to spread?

Fighting prostate cancer: John's Mayo Clinic story

Best Answer

This is because, unlike many other cancers, prostate cancer usually progresses very slowly.

It can take up to 15 years for the cancer to spread from the prostate to other parts of the body (metastasis), typically the bones.

What Everyone Should Know About Prostate Cancer

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Related Questions

How long does it take cervical cancer to spread?

How long does it take for cervical cancer to develop? Once cervical cells begin to change, it typically takes 10-15 years before invasive cervical cancer develops.

Is prostate cancer fast spreading?

Prostate cancer lives as it is born: slow-growing and benign or fast-growing and dangerous. This year, more than 238,000 American men will be diagnosed with prostate cancer. In most cases, the cancer consists of small knots of abnormal cells growing slowly in the walnut-sized prostate gland.

How long does it take for ringworm to spread?

In general, ringworm is not contagious about 24-48 hours after topical medication treatment. However, treatment protocols usually require about one to two weeks of treatment. If treatment is interrupted or not completed, it is possible to have ringworm reoccur.

What are the Signs and Symptoms of Prostate Cancer? | Cancer Research UK

How long does prostatitis take to clear?

For acute prostatitis, antibiotics are taken for 2 to 6 weeks. Chronic prostatitis is treated with antibiotics for 4 to 12 weeks or longer. Finish all the antibiotics, even if you start feeling better. It is harder for antibiotics to get into prostate tissue to treat the infection.

How long does it take for melanoma to spread?

Melanoma can grow very quickly. It can become life-threatening in as little as six weeks and if untreated, it can spread to other parts of the body. It can appear on skin not normally exposed to the sun. Nodular melanoma is a highly dangerous form of melanoma that looks different from common melanomas.

How long does it take for cancer to kill you?

Overall, more than 50% of people diagnosed with cancer live for more than 5 years. Some cancers have survival rates of more than 90%. Cancer at an early stage does not kill you. So a lot of effort is put into early diagnosis when treatment is likely to work best.

How long does it take for breast cancer to develop?

Breast cancer has to divide 30 times before it can be felt. Up to the 28th cell division, neither you nor your doctor can detect it by hand. With most breast cancers, each division takes one to two months, so by the time you can feel a cancerous lump, the cancer has been in your body for two to five years.

How long does cancer take to develop?

It takes at least 30 divisions of one cancer cell to create a tumor that is 1 centimeter in size (about half an inch). That is the smallest size likely to be seen on an X-ray. It takes about three to six months for most lung cancers to double their size.

Metastatic Prostate Cancer Treatment Options

What are the signs that prostate cancer has spread?

Once prostate cancer has spread to the bones, symptoms can include: bone pain. weak bones that are more likely to fracture. pain or stiffness in the neck or back. trouble urinating. constipation. numbness and weakness from spinal cord compression.

How does bone cancer spread?

The bone is a common site for metastasis. Bone metastasis or "bone mets" occurs when cancer cells from the primary tumor relocate to the bone. Prostate, breast, and lung cancers are most likely to spread to the bone. Prostate cancer cells from the primary tumor can break away and get into the bloodstream.

Does biopsy cause cancer to spread?

Fine needle aspiration is a minimally invasive technique that uses a thin and hollow needle to extract a few cells from a tumor mass. A long-held belief by a number of patients and even some physicians has been that a biopsy can cause some cancer cells to spread.

How long does HPV take to cause cancer?

Research has found that it can take 10 to 20 years, or even longer, for HPV-infected cervical cells to develop into a cancerous tumor.

How long does cervical cancer take to develop?

Once cervical cells begin to change, it typically takes 10-15 years before invasive cervical cancer develops. As the cells change, they first become "pre-cancerous" – a condition also known as "dysplasia" or CIN – the abbreviation for cervical intraepithelial neoplasia.

How Cancer Spreads (Metastasis) - Michael Henry, PhD

How long does it take to reincarnate?

From Buddhism, we learn that the stream of consciousness reincarnates generally between 49 days and two years after death. From Christianity, we learn that the soul can reincarnate at anytime after a death.

Is it painful to die of prostate cancer?

Many people worry about being in pain when they are dying. Some people do get pain if their prostate cancer presses on their nerves or makes their bones weak. But not everyone dying from prostate cancer has pain. You should tell your doctor or nurse if you're in pain or if your pain gets worse.

How quickly does prostate cancer grow?

Prostate cancer lives as it is born: slow-growing and benign or fast-growing and dangerous. This year, more than 238,000 American men will be diagnosed with prostate cancer. In most cases, the cancer consists of small knots of abnormal cells growing slowly in the walnut-sized prostate gland.

How long does it take to adopt?

The time frame, like the cost, varies with the type of child being adopted. With a completed homestudy in hand, the process to adopt a child with special needs can often proceed quickly and be completed within a few months. The wait is typically between two and seven years for a healthy infant.

How does cancer spread from one person to another?

Cancer is NOT contagious. There is no evidence that close contact or things like sex, kissing, touching, sharing meals, or breathing the same air can spread cancer from one person to another. Cancer cells from one person are generally unable to live in the body of another healthy person.

Can prostatitis lead to cancer?

Occasionally, inflammation due to prostatitis can raise your PSA level (prostate-specific antigen). However, it does not lead to cancer. Prostate cancer is believed to be due to a combination of factors including diet, lifestyle, genetics, and environmental exposures.

How long does it take to get CT scan results for cancer?

A CT scan can help doctors find cancer and show things like a tumor's shape and size. CT scans are most often an outpatient procedure. The scan is painless and takes about 10 to 30 minutes.

Does enlarged prostate mean cancer?

An enlarged prostate means the gland has grown bigger. Prostate enlargement happens to almost all men as they get older. An enlarged prostate is often called benign prostatic hyperplasia (BPH). It is not cancer, and it does not raise your risk for prostate cancer.

How long can you live with prostate cancer?

92% of all prostate cancers are found when they are in the early stage, called local or regional. Almost 100% of men who have local or regional prostate cancer will survive more than five years after diagnosis.

How long does it take for precancerous cells to turn into cancer?

Once cervical cells begin to change, it typically takes 10-15 years before invasive cervical cancer develops. As the cells change, they first become "pre-cancerous" – a condition also known as "dysplasia" or CIN – the abbreviation for cervical intraepithelial neoplasia.

How long does it take to get PET scan results for cancer?

After the radiotracer is injected into a vein, it usually takes up to one hour to travel throughout the body and be absorbed into the organs or tissues that are being examined. The PET scan itself may take another 30 to 60 minutes. Heart and brain studies take less time for imaging.

How long does it take for tramadol to take effect?

You will feel less pain 30 to 60 minutes after taking fast-acting tramadol. The pain relief wears off after 4 to 6 hours. Slow-acting tramadol tablets and capsules can take a day or two to start working but the pain relief will last for longer.

How long does it take for Dewormer to take effect?

Your puppy will begin passing worms approximately 12 hours following the administration of the dewormer, and he'll continue to poop worms for several days. In some cases, it may take up as long as 2 weeks to completely expel them from his body.

How long does it take for mirtazapine to take effect?

Sleep, energy, or appetite may show some improvement within the first 1-2 weeks. Improvement in these physical symptoms can be an important early signal that the medication is working. Depressed mood and lack of interest in activities may need up to 6-8 weeks to fully improve.

Does bladder cancer spread quickly?

Malignant cancers can be life-threatening as they can spread quickly. Untreated, they can damage tissues and organs and spread to other parts of the body. Half of all cases are found when the cancer is still only in the bladder, but 4 percent of diagnoses are made after bladder cancer has spread to distant tissues.

How long does it take for Trilostane to take effect?

Clinical improvement is usually seen within 2 weeks of starting trilostane and in those dogs that respond to trilostane, adequate control is invariably achieved within 30 d of starting medication.

How long does it take for frontline to take effect?

Frontline Plus can get rid of all fleas within 12 hours along with all lice and ticks within 48 hours.

Does testicular cancer spread quickly?

Most testicular cancers start in the cells that make sperm. The 2 most common types of testicular cancer are: Seminomas. These tumors tend to grow and spread slower than most other testicular cancers.

How long does it take for Metacam to take effect?

Maximum effect is seen approximately 8 hours after administration. When beginning a trial course of meloxicam, a response may take 3 or 4 days to show. If no response has been seen in 10 days, meloxicam has failed and a different pain medication should be tried. If one NSAID fails, another may well work.

Does tongue cancer spread quickly?

If the cancer is found early, before it has spread to other tissues, the cure rate is nearly 90%. More than half of oral cancers have spread when the cancer is detected. Most have spread to the throat or neck. It is possible, but not fully proven, that cancers that test positive for HPV may have a better outlook.

Does bone cancer spread quickly?

The outlook for a patient with malignant bone cancer depends mainly on whether it has spread to other parts of the body. If the cancer is localized (has not spread), the prognosis is usually good.

Does liver cancer spread quickly?

Cancer can start any place in the body. Liver cancer starts in the liver. It starts when cells in the liver grow out of control and crowd out normal cells. Cancer cells can spread to other parts of the body.

How long does it take to get promoted to detective?

Becoming a police officer requires about six months of training, and officers must typically gain four or five years or experience before they can take a promotional exam to become a detective. Some police departments allow officers to substitute a college degree for a year of experience.

How do you rule out prostate cancer?

During a DRE , your doctor inserts a gloved, lubricated finger into your rectum to examine your prostate, which is adjacent to the rectum. If your doctor finds any abnormalities in the texture, shape or size of the gland, you may need further tests. Prostate-specific antigen (PSA) test.

How long does it take a dog to fully mature?

Small breeds are dogs up to 30 pounds when fully grown. Medium breeds reach full growth between 12 to 16 months of age. Medium breeds are dogs between 30 and 80 pounds when fully grown. Large dogs or large breeds can take as long as two years to reach their final size.

How long does it take ear mites to die?

If using a single use product such as Revolution one dose is often enough to get rid of an ear mite infection but it will still take up to three or four weeks for the infection to completely clear up.

How long does it take for probiotics to work?

Within 30 to 60 minutes. Assuming that I administer a high-quality probiotic supplement that's properly formatted in a way that allows its microbial constituents to survive my stomach acidity – and colonize within my gut, I generally notice an effect within 30 to 60 minutes of administration.

How long does it take to die from radiation?

If 100 people get a sudden dose of 350 rems of radiation, about 3.5 sieverts, then about half of them will die in 60 days. 350 rems is considered LD50/60. It means what you think. 50% death rate in 60 days.

How long does it take for c5 vaccination to work?

Once a vaccination has been administered, immunity can take days to weeks to develop. To ensure they have optimum protection, ideally your dog or cat should be fully vaccinated (including boosters if required) 2 to 4 weeks before entering a boarding kennel.

How long does it take to show signs of chlamydia?

Most people who have chlamydia don't notice any symptoms. If you do get symptoms, these usually appear between 1 and 3 weeks after having unprotected sex with an infected person. For some people they don't develop until many months later. Sometimes the symptoms can disappear after a few days.

How long does it take to get rid of scabies?

For the first few days to a week, the rash and itch can worsen during treatment. Within 4 weeks, your skin should heal. If your skin has not healed within 4 weeks, you may still have mites. Some people need to treat 2 or 3 times to get rid of the mites.

How long does it take to fully train a dog?

Potty training is an important step in training your dog. Training a puppy to pee outside takes 4 to 6 months on average, but it can be a lot quicker if you are very consistent about taking your puppy outside every few hours. Some puppies can be potty trained in as little as two weeks.

How long does it take to wake up after surgery?

It usually takes about 45 minutes to an hour to recover completely from general anesthesia. In some cases, this period may be a bit longer depending on medications given during or after surgery.

How long does it take to cure UTI in dogs?

Agents that soothe the urinary bladder such as Cosequin also may be useful in cats. The symptoms of your pet's urinary tract infection will usually dramatically decrease within two to four days of therapy. Prognosis of a cure for simple urinary tract infections is excellent after a two-week course of therapy.

How long does it take for pet ease to work?

Works great for our dog, but the trick is to make sure you give it to your dog an hour ahead of time. Our dog gets super-anxious on trips over about 15 minutes. He pants heavily and is very restless. We gave them these 30 minutes before a trip about four times and saw no improvement in our dog's behavior.

How long does it take to train a military dog?

The US Army recommends handlers train with their dogs a minimum of 4 hours per week. In other words, handlers should practice with their dogs at least 30 minutes a day.

How long does it take to recover from h3n2?

Symptoms usually appear from one to four days after exposure to the virus, and they last five to seven days.

How long does it take someone to find a job?

Overall, the average job-search process takes just over six weeks— 43 days, to be exact— but that varies considerably by industry. According to Jobvite's 2014 data, jobs are filled most quickly by hospitality and retail employers, at 36 and 40 days, respectively.

How long does it take for stereotactic radiation to work?

The procedure may take less than an hour to about four hours, depending on the size and shape of the target. If treating with LINAC stereotactic radiosurgery of the brain the treatment will be quicker. A radiation oncologist monitors the Gamma Knife procedure in progress.

How long does it take to treat roundworms in dogs?

In the case of the three-dose regimen, the pet will receive one initial dose, then two more doses 7-10 days apart (allowing time for existing eggs to hatch and become susceptible to the medication). Puppies can be dewormed as early as 2 weeks of age, depending on the medication.

How long does it take frontline to kill fleas?

Frontline Plus can get rid of all fleas within 12 hours along with all lice and ticks within 48 hours.

How long does it take for Frontline Plus to work?

How Long Does it Take Frontline Plus To Work? Frontline Plus will get rid of all fleas within 18 hours of contact with your pet and will kill all ticks within 48 hours after coming in contact with your pet.

How long does it take to train a puppy?

Potty Training. Potty training is an important step in training your dog. Training a puppy to pee outside takes 4 to 6 months on average, but it can be a lot quicker if you are very consistent about taking your puppy outside every few hours. Some puppies can be potty trained in as little as two weeks.

How long does it take to heal after root canal?

A successful root canal can cause mild pain for a few days. This is temporary, and should go away on its own as long as you practice good oral hygiene. You should see your dentist for a follow-up if the pain lasts longer than three days.

How long does it take to kill fleas?

You'll be glad to know that it actually only takes about 1-2 days of diligence to completely rid your house of fleas (for even the worst infestations), as long as you do it right.

How long does it take dogs to poop after eating?

Every dog is different, and while some will poop right after eating, others may not go for about half an hour after consuming their meal. PetMD explains that healthy dogs usually defecate after eating their meals because their stomach "is wired to" the colon by nerves triggering the reflex to eliminate.

How long does it take for Threadworm to die?

Do not be alarmed! Ask your chemist for advice on treatment in the next day or so. Threadworms live about 5-6 weeks in the gut, and then die. However, before they die the female worms lay tiny eggs around the anus.

How long does it take to treat hookworm in dogs?

Therefore, it is necessary to treat an infected dog again in about two to four weeks to kill any newly developed adult worms that were larvae at the time of the first treatment. In rare cases, a blood transfusion may be necessary in dogs with severe anemia.

How long does it take for Kaopectate to work?

Do not take more than eight doses. If Kaopectate does not help in 12 hours, take two tablets of Imodium after each loose stool. Do not take more than eight tablets in 24 hours.

How long does it take to fix underbite with braces?

The length of time it takes for braces to correct an underbite varies between patients and is heavily dependent on the severity of the underbite, but patients typically wear the braces for 1 to 3 years or more, as stated by Dental Associates. Refer to a licensed orthodontist for an accurate prognosis.

How long does it take for puppies to walk?

As soon as the puppies' eyes open, they rapidly begin to mature physically. By two weeks of age, they should be alert and trying to stand. By three weeks, they should be trying to climb out of their nest or whelping box. By four weeks, all the puppies should be able to walk, run, and play.

How long does it take to potty train a pug?

And, that when you are not home to take your Pug there, pee pads are used for bathroom needs. While the exact time needed for potty training varies depending on how often you are there to actually teach the lessons, expect for this to take about 3 months for your Pug to be fully trained.

How long does it take to get reincarnated?

From Buddhism, we learn that the stream of consciousness reincarnates generally between 49 days and two years after death. From Christianity, we learn that the soul can reincarnate at anytime after a death.

How long does it take to kill bed bugs?

Depending on the individual spray, and the conditions of where it was used, a residual insecticide could be effective for anywhere from two weeks to over a year. The time from exposure to death will also vary - some sprays can kill exposed bed bugs in under a minute, while others take several minutes to work.

How long does it take for dog nail to heal?

Generally, dogs start feeling better within 48 hours. Total recovery takes some time, as the nail needs to re-grow so to completely cover the vulnerable quick. Generally, this takes 2 weeks according to Dr. Fiona. As your dog recovers, try to avoid walking him on rocks, sand, snow, or mud for about two weeks.

How long does it take for Galliprant to work?

Galliprant will begin to work shortly after it is given, but signs/symptoms continue to improve for four weeks after the first daily dose. Currently, Galliprant is not labeled for use with NSAIDs or steroids.

How long does it take to brush a dog?

You should brush only for as long as it takes to remove any tangles, loose hair or dirt on your dog's body. For short-haired dogs, this may only take a couple of minutes. A long-haired dog might take 15 to 30 minutes, depending on the thickness and condition of his coat.

How long does it take for mastitis to go away?

Fever is often gone by 24 hours, the pain within 24 to 72 hours and the breast lump disappears over the next 5 to 7 days. Occasionally the lump takes longer than 7 days to disappear completely, but as long as it's getting small, this is a good thing.

How long does it take for poop to dissolve?

Whichever way you choose, pour the water for a few minutes, until only the hot water remains in the toilet, and then wait for another few minutes to soften the poop. After approximately 5 minutes, you should flush the water normally, and the poop will leave the toilet.

How long does it take metacam to work in dogs?

Maximum effect is seen approximately 8 hours after administration. When beginning a trial course of meloxicam, a response may take 3 or 4 days to show. If no response has been seen in 10 days, meloxicam has failed and a different pain medication should be tried. If one NSAID fails, another may well work.

How long does it take to install invisible fence?

Overview of Dog Fence Installation. You should set aside about ten hours for the whole installation project. The first and second steps will take about an hour. Burying the wire will take about four hours (if you use a trencher or edger.

How long does it take to stop the flea cycle?

It is important to kill fleas quickly before their life cycle can be completed and an infestation develops. The flea life cycle can take as little as 12 to 14 days or as long as 180 days. Under typical household conditions, a complete lifecycle usually takes 3 to 6 weeks.

How long does it take to kill roundworms?

The dead and dying roundworms pass into the stool after administration of the anthelmintic or deworming medication. Since none of these treatments will kill the immature forms of the worm or the migrating larvae, at least two or three treatments are needed. Treatments are typically done at two to three week intervals.

How long does it take for cropped ears to heal?

Some vets prefer to wait until the incisions have healed a little before posting the ears. Bandage changes are typically done weekly, and the ears remain taped and propped up until they stand on their own. The healing process can take 4-8 weeks.

How long does it take for dwellers to get pregnant?

Make sure to assign at least one male/non-pregnant Dweller to all stations and don't equip pregnant women with weapons since they don't use them. Deliver Baby: After mating it takes 3 hours for a baby to be born. You do not have to be in the game for this whole time. Just come back after 3 hours and you'll have a baby.

How long does it take for Cat dewormer to work?

Most medications are able to kill adult worms within 24 hours of intake. In some special cases, it takes a second dose between 3 and 4 weeks later to kill the rest, which was larvae at the time of treatment. On the whole, a cat is likely to re-contract worms shortly after receiving a deworming dosage.

How long does it take for cropped ears to stand?

A perfect crop can be a flop if the aftercare is not handled correctly. Most pit bulls, amstaffs, min pins, and miniature schnauzers require only 3 or 4 taping appointments and the ears will stand. Other breeds like dobes, danes, and boxers may require 4-6 months of proper taping until the ears will stand.

How long does it take for baking soda to deodorize?

Let the baking soda sit for several hours or overnight. If you can let it sit for 24 hours, that's even better. The longer it sits, the better your results will be. Baking soda naturally neutralizes and absorbs odors rather than covering them up.

How long does it take to clean a dog's teeth?

12. How long does a dental cleaning procedure take? Dental cleanings typically take anywhere from 45 to 75 minutes depending on the amount of tartar in the mouth, the dental disease present, and the number of dental x-rays that need to be taken. Dental extraction procedures typically take anywhere from 1-2.5 hours.

How long does it take for NexGard to kick in?

NexGard kills fleas within 8 hours and ticks within 48 hours. After being given, its actions last for at least 5 weeks against fleas and up to one month against ticks.

How long does it take for Frostnip to heal?

The recovery time for a frostbite injury depends on the extent of tissue injury and whether or not there are any subsequent complications, such as infection. It may take 1 to 3 months before it is possible to determine the extent of tissue damage, and to clearly delineate which tissue is still viable.

How long does it take to recover from frostbite?

The recovery time for a frostbite injury depends on the extent of tissue injury and whether or not there are any subsequent complications, such as infection. It may take 1 to 3 months before it is possible to determine the extent of tissue damage, and to clearly delineate which tissue is still viable.

How long does it take for gabapentin to kick in?

By altering the way nerves work, gabapentin may reduce your pain. You should notice that your pain starts to improve over one to two weeks after starting gabapentin, but it may take longer in some people. However, some feel benefit straight away.

How long does a dog take to learn its name?

When he looks at you, say his name and give him a dog treat. As an option, use a clicker before giving the treat. Do this for five to 10 minutes daily, and within days, you'll be able to say his name and get his attention as he looks at you in anticipation of a treat.

How long does it take for chlamydia to show?

Most people who have chlamydia don't notice any symptoms. If you do get symptoms, these usually appear between 1 and 3 weeks after having unprotected sex with an infected person. For some people they don't develop until many months later. Sometimes the symptoms can disappear after a few days.

How long does it take for a tick to embed?

TERC Answer: The length of time a tick stays attached depends on the tick species, tick life stage and the host immunity. It also depends on whether you do a daily tick check. Generally if undisturbed, larvae remain attached and feeding for about 3 days, nymphs for 3-4 days, and adult females for 7-10 days.

How long does it take for a puppy to latch?

This instinct ensures that they remain warm and that they drink colostrum. Puppies who fail to nurse shortly after birth may need assistance nursing so that they receive the benefits of this early breast milk. Puppies should nurse approximately every two hours for their first two weeks of life.

How long does it take hemorrhoids to go away?

Small hemorrhoids may clear up without any treatment within a few days. Large, external hemorrhoids may take longer to heal and can cause significant pain and discomfort. If hemorrhoids have not resolved within a few days, it is best to see a doctor for treatment.

How long does it take to get a foster child?

How Long Does It Take to Become a Foster Parent? The time it takes to become a foster parent varies for everyone. Typically, the licensing process can take anywhere from three to six months or longer. It would be difficult to complete everything in less than three months, but it's not necessarily impossible.

How long does it take Yorkies to have puppies?

Canines in general are pregnant for an average of 63 days. However, as few as 58 days and as long as 68 days of pregnancy is considered normal for a toy breed dog. If a Yorkie has not delivered by day 67, it will be time to call the veterinarian.

How long does it take for scabs to heal?

Most scrapes heal well with home treatment and do not scar. Minor scrapes may be uncomfortable, but they usually heal within 3 to 7 days. The larger and deeper the scrape, the longer it will take to heal. A large, deep scrape may take up to 1 to 2 weeks or longer to heal.

How long does it take for revolution to kill mites?

To ensure all mite eggs have been eliminated treatment needs to continue for a minimum of 3 weeks. If using a single use product such as Revolution one dose is often enough to get rid of an ear mite infection but it will still take up to three or four weeks for the infection to completely clear up.

How long does it take to train a bird dog?

In that four months the dog will be obedience trained, force broken, taught to quarter in the field and work to the whistle, and lay steady at a duck blind. That is a basic gun dog course. If you want the dog to run short blinds and take hand signals, he'll be there for another four to six months.

How long does it take for drontal to kick in?

How Long Will Drontal Take to Work? Most of the time, the medication will start working immediately. Many owners said that their puppy or adult dog's stools were free from worms within 24 hours – however, it has been reported to work in as little as 8 hours!

How long does it take poison ivy to show up?

The symptoms vary in severity from person to person. The plant oil can begin to penetrate the skin within 5-10 minutes of contact. Poison ivy rash can appear in as little as 4 hours or as long as 2-3 weeks after exposure. Generally, the first blisters appear within 1-14 days.

How long does it take probiotics to work in dogs?

Furthermore, it is entirely possible that some dogs may take a couple of days for their digestive system to balance and for the probiotic to really start working. Long-term effects may take up to a few weeks for pet owners to see a noticeable change.

How long does it take for Ebola to kill you?

Recovery may begin between 7 and 14 days after first symptoms. Death, if it occurs, follows typically 6 to 16 days from first symptoms and is often due to low blood pressure from fluid loss. In general, bleeding often indicates a worse outcome, and blood loss may result in death.