How quickly does prednisone work?

High-Dose Steroids Could Make Asthma Worse

Best Answer

Prednisone generally works very quickly — usually within one to four days — if the prescribed dose is adequate to reduce your particular level of inflammation.

Some people notice the effects of prednisone hours after taking the first dose.

The Dangers of Prednisone

Previous QuestionHow long do steroid side effects last?
Next QuestionWhy do steroids keep you awake?

Related Questions

How quickly does Phentermine work?

After a dosage, phentermine is absorbed through the gastrointestinal tract and reaches peak concentrations in the blood in three to 4.4 hours. It has a half-life of about 25 hours, which is the time it takes for half of the dosage to be metabolized by the liver or excreted unchanged in the urine. It takes five to six.

How quickly does Heartgard work?

The low dose of ivermectin is metabolized and excreted rapidly, so it kills heartworm larvae present today but does not have an effect on larvae introduced tomorrow. That is why it is recommended to administer HEARTGARD Plus every 30 days. Pyrantel pamoate kills roundworms and hookworms living in your dog's intestines.

How quickly does NexGard work?

NexGard kills fleas within 8 hours and ticks within 48 hours. After being given, its actions last for at least 5 weeks against fleas and up to one month against ticks.

What Are the Side Effects of Treatment With Corticosteroids?

How quickly does Cytopoint work?

Cytopoint reduces pruritus within 24 hours and delivers four to eight weeks of itch relief in most patients. While Cytopoint rapidly reduces itch, the return of clinical signs is gradual, allowing the veterinarian to repeat dosing as determined by the return of pruritus.

How quickly does Vetoryl work?

The results of routine blood tests, including electrolytes, and an ACTH stimulation test are used to assess the effectiveness of VETORYL Capsules at 10-14 days, 4 weeks and 12 weeks after starting your dog on treatment, and every 3 months thereafter.

How quickly does Adaptil work?

How fast will it work? In 24 hours, the Diffuser will be fully functional and ADAPTIL will spread in your home. For situations that can be anticipated like fireworks, you should plug in the Diffuser 2-3 days in advance.

How quickly does Benadryl work?

Benadryl is quickly absorbed after oral administration and peak effects are reached within one hour. The effects of diphenhydramine last from four to six hours. Benadryl in the injectable form has a rapid onset of action. When used as a night-time sleeping aid, the usual dosage of Benadryl is 50mg at bedtime.

How quickly does Droncit work?

Droncit works fairly quickly with peak blood levels reached within 30 minutes to 2 hours. The exact mechanism for how it works hasn't been 100% determined, but it is thought to affect their ability to hook onto the intestinal wall, and causes damage to their "skin." The body then digest the worm and it is absorbed.

TIPS TO GET RID OF YOUR MOON FACE WHILE ON PREDNISONE!!!

How quickly does Diazepam work?

Oral: Bioavailability is 100% and will take up to 40 minutes to take effect. Peak pharmacological effects set in 30-90 minutes after administration. Intravenous (IV): Taken in diluted form due to its damaging effects on veins, bioavailability is 100% and once taken, effects set in within 1-5 minutes.

How quickly does loratadine work?

Loratadine's peak effect occurs after 1-2 hours, and its biological half life is on average 8 hours (range 3 to 20 hours) with desloratadine's half-life being 27 hours (range 9 to 92 hours), accounting for its long-lasting effect.

How quickly does metronidazole work?

Most courses of metronidazole last for around 7 days, but some may be as short as 3 days and some as long as 14 days. For certain infections you may be given a single, larger dose of metronidazole, usually five 400 mg tablets (2 g) to take at once. Take each of your doses with a snack or just after eating a meal.

How quickly does amoxicillin work?

Antibiotics begin to work right after you start taking them. However, you might not feel better for two to three days. How quickly you get better after antibiotic treatment varies. It also depends on the type of infection you're treating.

How quickly does Zantac work?

Maximum Strength Zantac 150® can be taken 30 to 60 minutes before eating food or drinking beverages that cause heartburn to prevent symptoms, or it can be taken when heartburn symptoms strike, providing relief in as little as 30 minutes and lasting up to 12 hours.

Asthma Myth: Use of steroids as a treatment option and its side effects

How quickly does NexGard start working?

NexGard kills fleas within 8 hours and ticks within 48 hours. After being given, its actions last for at least 5 weeks against fleas and up to one month against ticks.

How does Capstar work so quickly?

Capstar contains the compound nitenpyram. Nitenpyram interferes with fleas' neurotransmission, killing them very quickly. A: Capstar begins working within 30 minutes. In clinical studies, Capstar achieved greater than 90 percent effectiveness against adult fleas within 4 hours on dogs and within 6 hours on cats.

How quickly does Cerenia work in dogs?

Cerenia has a rapid onset of activity, eliminating vomiting 39 minutes (on average) post administration. Any dog, 16 weeks of age or older, for which you would normally prescribe an antiemetic.

How quickly does tapeworm medicine work?

Most tapeworm medications kill the adult tapeworms within 24 hours after they are given. In some cases a second dose is needed 3-4 weeks later to kill any remaining adults and those that were larva at the time of the treatment.

How quickly does metronidazole work for BV?

If symptoms improve after treatment, a follow-up visit is not necessary. Metronidazole — Metronidazole vaginal gel is one of the most effective treatments; it is applied inside the vagina at bedtime for five days. Metronidazole can also be taken in pill form, 500 mg twice daily for seven days.

How quickly does propranolol work for anxiety?

When used for anxiety, propranolol doses are typically 10mg to 40mg. Some people use these medications as needed for certain events that cause them anxiety. When this is the case, they might just take propranolol 30 minutes to one hour before the event. Other people take propranolol for more generalized anxiety.

How quickly does flea treatment work?

Advantage contains an active ingredient that spreads quickly from the point of application, killing fleas within one day and preventing further infestations for up to four weeks in dogs, three to four weeks in cats and one week in rabbits.

How quickly does Pepto Bismol work?

If you're using the suspension, shake the bottle before taking a dose. Adults aged 16 years and over should take 30ml Pepto-bismol liquid OR two Pepto-bismol tablets when needed to relieve symptoms. This dose can be repeated after 30 to 60 minutes if needed. Do not take more than eight doses in 24 hours.

How quickly does drontal work in dogs?

How quickly does Drontal work? Drontal starts working as soon as it is ingested. Worms, if present, may or may not appear in the droppings for up to 48 hours after treatment.

How quickly does adequan work in dogs?

It goes to work in the joint in about two hours and stays in the joint for about three days.With Adequan Canine you should see signs of improvement within four weeks. Your dog may begin to act like the playful, active dog you remember.

How quickly do antihistamines work?

Usually, antihistamine tablets start to work within 30 minutes after being taken and tend to be most effective within 1-2 hours after being taken. Antihistamines are more effective when taken regularly as a prevention, before symptoms occur, rather than only when you have symptoms.

How quickly does coconut oil work for yeast infection?

When a person uses coconut oil to treat a yeast infection in the mouth, they should do the following: Melt the coconut oil in the microwave for a few seconds. When it is cool enough to not burn the skin, swish in the mouth for about 30 seconds. Spit out the coconut oil.

How long does it take prednisone to work on a dog?

In general, if your dog is taking the prednisone for 1 to 4 weeks then he may not experience many side effects. Side effects tend to become more common in dogs who are on prednisone for a long time.

How long does it take for prednisone to start working in dogs?

Prednisone generally works very quickly — usually within one to four days — if the prescribed dose is adequate to reduce your particular level of inflammation. Some people notice the effects of prednisone hours after taking the first dose.

How long does it take for prednisone to work in dogs?

Prednisone generally works very quickly — usually within one to four days — if the prescribed dose is adequate to reduce your particular level of inflammation. Some people notice the effects of prednisone hours after taking the first dose.

How long does it take for prednisone to work in dogs with lymphoma?

Without any treatment, the average survival for dogs with lymphoma is 4 to 6 weeks. Approximately 50% of dogs with lymphoma will respond to prednisone (a steroid) alone, but the remission times are only 2 to 4 months with prednisone alone.

How quickly does Dramamine?

To prevent motion sickness, the first dose should be taken 30 minutes to 1 hour before you travel or begin motion activity. Adults and children older than age 12 may usually take dimenhydrinate every 4 to 6 hours as needed to prevent or treat motion sickness.

How quickly does tetanus kill?

Tetanus symptoms usually emerge about 7 to 10 days after initial infection. However, this can vary from 4 days to about 3 weeks, and may, in some cases, may take months. In general, the further the injury site is from the central nervous system, the longer the incubation period.

How quickly does pancreatitis develop?

In acute pancreatitis, inflammation develops quickly and subsides within a few days but can last for to a few weeks. In chronic pancreatitis, the pancreas is persistently inflamed, which causes permanent damage.

How quickly does ALS progress?

The rate at which ALS progresses can be quite variable from one person to another. Although the mean survival time with ALS is three to five years, many people live five, 10 or more years. Symptoms can begin in the muscles that control speech and swallowing or in the hands, arms, legs or feet.

How quickly does lymphoma progress?

After five to 10 years, low-grade disorders begin to progress rapidly to become aggressive or high-grade and produce more severe symptoms. This type progresses fairly rapidly without treatment. With treatment, remission can be induced in between 50 to 75 percent of cases.

How quickly does frostbite happen?

On exposed skin, with wind chill values between -10 and -20 degrees, frostbite can happen in 30 minutes. As wind chills climb to -20 to -30, it could happen in as little as 10 minutes.

How quickly does leukemia develop?

Acute leukemias — which are incredibly rare — are the most rapidly progressing cancer we know of. The white cells in the blood grow very quickly, over a matter of days to weeks. Sometimes a patient with acute leukemia has no symptoms or has normal blood work even a few weeks or months before the diagnosis.

How quickly does parvo progress?

Parvo was discovered in the 1970's, and in two years, the virus spread worldwide. Dogs that develop parvo will show symptoms 3-10 days after being exposed. Symptoms include: vomiting, lethargy, diarrhea (usually bloody), and fever. Mortality rate: 90 percent if left untreated, 5-20 percent if aggressively treated.

How quickly does lymphoma grow?

Chemotherapy combinations cure about 50 percent of patients, meaning there are many who need other choices. This lymphoma is very rapidly growing, and lymph nodes double in size within a few days to a few weeks. While it is rapidly growing, it is curable in many patients when diagnosed early.

How quickly does vitiligo progress?

Nonsegmental vitiligo usually spreads. For some people, the white patches spread very slowly, maybe over a period of several years, but in others, they spread very quickly. For some people, the patches do not spread at all.

How does prednisone make you feel?

Prednisone is a corticosteroid medication often prescribed to help suppress the immune system and reduce inflammation in the body. While it can be quite effective in controlling symptoms, it can also cause a variety of side effects, including weight gain, increased appetite, excessive sweating and mood swings.

How quickly does scabies progress?

After the mite burrows into the skin, it takes time to develop signs and symptoms. If you've had scabies before, the itching usually begins within 1 to 4 days. When a person has not had scabies, the body needs time to develop a reaction to the mite. It can take 2 to 6 weeks to develop symptoms.

How quickly does lymphoma develop?

This lymphoma is very rapidly growing, and lymph nodes double in size within a few days to a few weeks. While it is rapidly growing, it is curable in many patients when diagnosed early.

How quickly does Lungworm develop?

How is lungworm infection diagnosed? The 'pre-patent period' (the time between when the animal was infected to when the parasite can be detected) is approximately 4 to 8 weeks, occasionally up to 15 weeks.

How quickly does heartworm progress?

Cats typically show symptoms of heartworm disease at two time points – when the immature heartworms arrive in the heart and lung arteries and when the adult heartworms die. The immature heartworms arrive in the heart and lung arteries about 3 to 4 months after a cat is bitten by an infected mosquito.

How quickly does cancer grow?

Scientists have found that for most breast and bowel cancers, the tumours begin to grow around ten years before they're detected. And for prostate cancer, tumours can be many decades old. “They've estimated that one tumour was 40 years old. Sometimes the growth can be really slow,” says Graham.

Does prednisone reduce tumors?

Prednisone is classified as a corticosteroid (more precisely a glucocorticosteroid), and has many uses in the treatment of cancer. One way that it works is to decrease inflammation (swelling). Corticosteroids may work by causing programmed cell death (apoptosis) of certain cells, which may help to fight your disease.

Does prednisone help cancer?

Prednisone is approved to be used to reduce inflammation and suppress (lower) the body's immune response. It is used with other drugs to treat the following types of cancer: Acute lymphoblastic leukemia (ALL).

Does prednisone reduce mucus?

Prednisone may be very effective in reducing airway inflammation, and related airway swelling, mucus production and breathlessness, but may be associated with side effects.

How quickly does frostbite set?

The chart below shows how long you can be exposed to certain temperatures before resulting in frostbite. For example, a temperature of 0 degrees Fahrenheit and a wind speed of 15 mph creates a wind chill temperature of -19 degrees Fahrenheit. Under these conditions frost bite can occur in just 30 minutes.

How quickly does ringworm grow?

How soon do symptoms appear? The incubation period is unknown for most of these agents, however ringworm of the scalp is usually seen 10 to 14 days after contact and ringworm of the body is seen 4 to 10 days after initial contact.

How quickly does osteosarcoma spread?

A metastatic osteosarcoma has clearly spread to other parts of the body. Most often it spreads to the lungs, but it can also spread to other bones, the brain, or other organs. About 1 out of 5 osteosarcomas has spread at the time of diagnosis.

How quickly does a puppy grow?

Dogs of this kind of size and weight typically stop growing somewhere between 6 and 8 months of age, but the vast majority of their growth is complete by around six months of age.

How quickly does NexGard kill ticks?

Fleas are typically killed within several hours, while ticks are killed within 1-2 days. It is important to note that Nexgard does not repel ticks. In some cases this means biting and attaching to your dog for up to 48 hours.

How quickly does revolution kill mites?

If using a single use product such as Revolution one dose is often enough to get rid of an ear mite infection but it will still take up to three or four weeks for the infection to completely clear up.

How quickly does a cataract progress?

Certain types of cataracts progress quite rapidly and cause cloudy vision within a few months. Fortunately, these are relatively uncommon. Most cataracts develop gradually and do not require surgery for many months or years.

How quickly does rigor mortis set in?

At the time of death, a condition called "primary flaccidity" occurs. Following this, the muscles stiffen in rigor mortis. All muscles in the body are affected. Starting between two and six hours following death, rigor mortis begins with the eyelids, neck, and jaw.

How quickly does periodontal disease progress?

This may progress and cause chronic periodontal destruction leading to loosening or loss of teeth. The dynamics of the disease are such that the individual can experience episodes of rapid periodontal disease activity in a relatively short period of time, followed by periods of remission.

Does prednisone make you poop?

Prednisone is a corticosteroid drug. There are several major side effects of prednisone which required medical attention such as black colored stool, abdominal pain, bloating, and diarrhea. One of the more serious side effects is that of the destruction of the intestinal flora, which can cause intestinal infections.

Does prednisone make you pee?

Taking prednisone can make the sugar (glucose) in your blood high. Signs that your sugar levels are high include: Feeling more thirsty than usual. Passing urine (peeing) more often.

Does prednisone mess with emotions?

Prednisone and Mood Swings. This medication is a corticosteroid that's prescribed for an array of conditions because it works to relieve inflammation in the body. Besides these rapid changes in mood, prednisone has been associated with more serious problems such as psychotic disorders, delusions, and dementia.

Does prednisone make dogs sleepy?

Side effects of prednisone in dogs may include increased thirst and hunger, panting, a loss of energy, vomiting, and/or skin infections. The steroid will affect each dog differently so you can't fully predict how your dog will react.

Does prednisone make you fat?

Weight gain from prednisone is usually caused by water retention and an increased appetite. Some people also experience body fat redistribution, a symptom that is characterized by fat deposits collecting in unusual areas like the base of the neck or back.

Does prednisone make you thirsty?

Your blood sugar can rise while you are taking prednisone. This can cause excessive thirst and frequent urination. If you have sleeping problems, ask your nurse or physician about changing the time of day prednisone is taken.

Does prednisone weaken your muscles?

One of the major problems of using steroids such as prednisone is they cause muscle wasting and weakness when taken long term. The study showed prednisone directs the production of annexins, proteins that stimulate muscle healing.

How quickly does DM progress in dogs?

The clinical course can range from 6 months to 1 year before dogs become paraplegic. If signs progress for a longer period of time, loss of urinary and fecal continence may occur and eventually weakness will develop in the front limbs. Another key feature of DM is that it is not a painful disease.

How quickly does a dogs progesterone rise?

The progesterone test can be done every 2-3 days starting about 3-5 days into the heat. Timing of the test can be more certain if the lengths of the dog's previous heat cycles are known. The beginning progesterone levels are typically less than 1.0 ng/ml until the day before the LH surge.

How quickly does the mouth heal?

Why cuts in your mouth heal 10 times faster than skin wounds. It's true – wounds in the mouth really do heal much faster than cuts to the skin. A study has discovered that the lining of the mouth is permanently primed for healing. The finding could lead to new ways to improve wound-healing elsewhere in the body.

How quickly does anaphylactic shock happen?

Anaphylactic reactions usually happen fast. Symptoms often become the most serious within 3 to 30 minutes of exposure to the allergy trigger. Quicker reactions are usually more severe.

How quickly does poison ivy show up?

The symptoms vary in severity from person to person. The plant oil can begin to penetrate the skin within 5-10 minutes of contact. Poison ivy rash can appear in as little as 4 hours or as long as 2-3 weeks after exposure. Generally, the first blisters appear within 1-14 days.

How quickly does aspiration pneumonia develop?

Symptoms of chemical pneumonitis include sudden shortness of breath and a cough that develops within minutes or hours. Other symptoms may include fever and pink frothy sputum. In less severe cases, the symptoms of aspiration pneumonia may occur a day or two after inhalation of the toxin.

How quickly does revolution kill ear mites?

If using a single use product such as Revolution one dose is often enough to get rid of an ear mite infection but it will still take up to three or four weeks for the infection to completely clear up.

How quickly does a puppy digest food?

For example, an average dog -- big or small -- takes between four and six hours to digest canned wet food. Digesting dry kibble, on the other hand, may take between eight and 10 hours.

How quickly does NexGard kill fleas?

How long does it take NexGard® to kill fleas? NexGard® will kill existing fleas within 8 hours of initial administration. Why am I seeing more fleas on my pet after administering NexGard®? NexGard® stimulates the fleas' nervous system, causing them to rise to the top of your dog's haircoat as they die.

How quickly does pink eye develop?

Pinkeye that's caused by bacteria can spread to others as soon as symptoms appear and for as long as there's discharge from the eye — or until 24 hours after antibiotics are started. Conjunctivitis that's caused by a virus is generally contagious before symptoms appear and can remain so as long as the symptoms last.

How quickly does ringworm show up?

How soon do symptoms appear? The incubation period is unknown for most of these agents, however ringworm of the scalp is usually seen 10 to 14 days after contact and ringworm of the body is seen 4 to 10 days after initial contact.

How quickly does prostate cancer grow?

Prostate cancer lives as it is born: slow-growing and benign or fast-growing and dangerous. This year, more than 238,000 American men will be diagnosed with prostate cancer. In most cases, the cancer consists of small knots of abnormal cells growing slowly in the walnut-sized prostate gland.

How quickly does degenerative myelopathy progress?

Canine degenerative myelopathy is a slowly progressive disease of the spinal cord. It has been compared to ALS in humans. The symptoms start gradually and the disease usually progresses through three distinct stages over the course of six months to a year.

How quickly does dog hair grow?

Generally, new hair growth is visible within a week or two. However, depending on the dog breed, the anogen or growth stage may last from one month to one year.

How quickly does impetigo show up?

Impetigo may develop up to 10 days after the skin becomes infected with the bacteria. Impetigo may be treated with an antibiotic taken by mouth or by application of an antibiotic ointment to the affected areas. A person with impetigo is probably no longer infectious after 24 hours of adequate antibiotic treatment.

How quickly does food poisoning start?

Food poisoning symptoms can begin as quickly as four hours or as long as 24 hours after eating contaminated food. People who eat the same contaminated food, say at a picnic or barbecue, will usually get sick about the same time.

How quickly does a dog's hair grow?

Generally, new hair growth is visible within a week or two. However, depending on the dog breed, the anogen or growth stage may last from one month to one year.

How quickly does Trifexis kill worms?

How quickly will Trifexis kill fleas? In a laboratory study of spinosad alone, this active ingredient of Trifexis started to kill fleas within 30 minutes and killed 100% of the fleas on dogs within 4 hours. Trifexis kills fleas before they can lay eggs.

How quickly does dengue fever start?

Many people, especially children and teens, may experience no signs or symptoms during a mild case of dengue fever. When symptoms do occur, they usually begin four to seven days after you are bitten by an infected mosquito.

Does vitiligo spread quickly?

Segmental vitiligo stays on one part of the body and does not spread. Nonsegmental vitiligo usually spreads. For some people, the white patches spread very slowly, maybe over a period of several years, but in others, they spread very quickly. For some people, the patches do not spread at all.

Does sarcoma spread quickly?

Most stage II and III sarcomas are high-grade tumors. They tend to grow and spread quickly. Even when these sarcomas have not yet spread to lymph nodes, the risk of spread (to lymph nodes or distant sites) is very high.

Does lymphoma spread quickly?

Non-Hodgkin lymphoma grows and spreads at different rates and can be indolent or aggressive. Indolent lymphoma tends to grow and spread slowly, and has few signs and symptoms. Aggressive lymphoma grows and spreads quickly, and has signs and symptoms that can be severe.

How long does prednisone stay in your system?

You could expect a dose or prednisone to be out of your system in 16.5 to 22 hours. The elimination half life of prednisone is around 3 to 4 hours. This is the time it takes for your body to reduce the plasma levels by half. It usually takes around 5.5 half lives for a drug to be completely eliminated from your system.

How long does prednisone stay in a dog's system?

Short-Term vs Long-Term. In general, if your dog is taking the prednisone for 1 to 4 weeks then he may not experience many side effects. Side effects tend to become more common in dogs who are on prednisone for a long time.

How does prednisone help mast cell tumors in dogs?

Benadryl – This is a H1 blocker that is given to block the effect of histamine release. Mast cell tumors have histamine in their granules. Prednisone – This is a steroid that is used to decrease inflammation associated with the mast cell tumor, and some mast cell tumors will respond to prednisone alone.

How does Euthanasia work?

Euthanasia is performed by the attending physician administering a fatal dose of a suitable drug to the patient on his or her express request. Palliative sedation is not a form of euthanasia: the patient is simply rendered unconscious with pain reducing drugs and eventually dies from natural causes.

How does Trilostane work?

Unlike Lysodren, which is a cytotoxic drug, Trilostane works as an enzyme blocker by inhibiting the production of cortisol at the level of the adrenal gland.

How does diarrhea work?

Osmotic diarrhea occurs when too much water is drawn into the bowels. Or it can be caused by osmotic laxatives (which work to alleviate constipation by drawing water into the bowels). In healthy individuals, too much magnesium or vitamin C or undigested lactose can produce osmotic diarrhea and distention of the bowel.

How does knockout work?

What is a knockout punch and how does it work? A good punch is a result of the entire body working in tandem. It can start at the feet, work its way up the rotating torso, and force itself through the shoulder muscles onto the fist.

Does MRSA spread quickly?

Anyone can get MRSA. MRSA is usually spread in the community by contact with infected people or things that are carrying the bacteria. This includes through contact with a contaminated wound or by sharing personal items, such as towels or razors, that have touched infected skin.

Does tongue cancer spread quickly?

If the cancer is found early, before it has spread to other tissues, the cure rate is nearly 90%. More than half of oral cancers have spread when the cancer is detected. Most have spread to the throat or neck. It is possible, but not fully proven, that cancers that test positive for HPV may have a better outlook.

How does EOS work?

The aim of EOS is to build a decentralized blockchain that can process fast and free transactions. It will also allow smart contracts to be built on top of it, which will allow developers to release dApps. For a complete guide on what a dApp is and how they work, click here!

How does monkey work?

Description: The Monkey app allows kids to have fun chats with new people from all over the world! Users are randomly matched with other users for a brief, introductory video call. When matched with a new person, you can add more time or add the person on Snapchat to continue the connection.

What does prednisone do for a dog?

Prednisone Directions: Prednisone is a prescription corticosteroid used in dogs and cats to treat various conditions such as Addison's disease, inflammation from arthritis, allergies, and certain autoimmune diseases.

Does prednisone cause muscle wasting in dogs?

One of the major problems of using steroids such as prednisone is they cause muscle wasting and weakness when taken long term. Daily doses of prednisone, however, reduced KLF15, leading to muscle wasting.

Does prednisone shrink tumors in dogs?

Prednisone has anti-cancer effects and can help dogs with lymphoma feel better for some period of time. Typically, the survival time for dogs with lymphoma receiving prednisone alone (i.e. without chemotherapy) is 1-3 months.