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When a pup has two different colored eyes, it's called heterochromia.

It's much more common in dogs, cats and horses.

The distribution of melanin in the iris determines eye color.

More melanin means he'll have a darker eye, like brown.

+8 votes
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Heterochromia is caused by a lack of the pigment melanin in all or part of one eye. In dogs with heterochromia, the lack of melanin causes one of their eyes to appear blue or bluish-white.

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