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Trazodone can both sedate a dog and relieve anxiety. This is a good dog sedative for grooming, veterinary visits, thunderstorms/fireworks, and other short-term stressful events. Side effects include low blood pressure, so trazodone may be used cautiously or avoided in patients with certain health conditions.
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Acepromazine is the most commonly prescribed oral sedative for dogs. Possible oral sedative combinations include:

  • acepromazine and Telazol powder (an anesthetic)
  • acepromazine and diazepam (an anti-anxiety drug)
  • diazepam and butorphanol (an opioid pain reliever)
  • phenobarbital and diazepam.
+6 votes
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Acepromazine is the most commonly prescribed oral sedative for dogs. It is a member of the phenothiazine class of sedatives and works primarily by blocking dopamine receptors within the brain, thereby depressing certain brain functions.
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Gabapentin is a medication that can be used for several purposes, including seizure control, anxiety relief, sedation, and pain management. It's a common dog sedative for grooming, travel, vet visits, and other short-term events. Gabapentin is generally considered safe in healthy pets, with minimal side effects.
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Trazodone. My sedative of choice for fearful stressed, or anxious dogs. Gentle on the liver, kidneys and GI tract, Trazodone relaxes dogs and decreases anxiety. Safe for use in both old and young dogs and comes in scored tablets for easy dosing.

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