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Frontline is one of the best and most successful topical treatment in killing fleas and ticks on pets.

It is also recommended by vets for both dogs and cats if they have trouble taking oral medication.

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  • Frontline Plus is an OTC product that uses fipronil and (S)-methoprene to attack fleas and ticks at every life stage. ...
  • Trifexis employs spinosad and milbemycin oxime to keep dogs protected from heartworms and intestinal parasites as well as fleas, but it does not work against ticks.

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