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For most dogs, the appropriate dosage of Benadryl is perfectly safe. It will begin to reduce symptoms like skin rashes in about an hour. Getting the dosage right is important because most Benadryl tablets are intended for humans. Some dogs can be quite small, so they need less Benadryl than a person.
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  • While Benadryl is considered safe for dogs, side effects and overdoses are possible. Common side effects of Benadryl include sleepiness, dry mouth, and retaining urine. Side effects that are less common include diarrhea, vomiting, loss of appetite, allergic reaction, and excitement.

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